Beschrijving

Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Vitamin K antagonists (VKA) are a class of anticoagulants. They reduce blood clotting by inhibiting the recycling of vitamin K epoxide back to the active reduced form of vitamin K. The term Vitamin K antagonists is a misnomer. These drugs do NOT antagonize the action of Vitamin K. See below for the mechanism of action. They can cause birth defects (teratogens). All VKAs can be neutralized in action by administration of vitamin K, although for the second generation \